Pathogenesis of HIT

burke_ae_16A-1Title of entry: Pathogenesis of HIT

Entrant’s name: Alison E Burke

Membership Type: Professional

Other contributors:

Address: Boston, MA

Client: The New England Journal of Medicine

Medium / software used: Adobe Illustrator and Adobe Photoshop

Final presentation format: Journal (print and online)

Primary audience: Physicians and Scientists

Intended purpose: The adverse drug effect known as heparin-induced thrombocytopenia (HIT)

shows many similarities to a bacterial host defense mechanism. The intended purpose of this

illustration was to demonstrate the similarities between these two mechanisms within a one panel

illustration for a comprehensive review article in the New England Journal of Medicine, a journal

whose audience consists of physicians and scientists.

The left side of the illustration, which includes warmer colors and background, represents the

heparin-induced pathway. The right side represents the innate bacterial host mechanism. Colorcoding

and negative space were used to divide the illustration visually, without adding an actual

division. The illustration was created using a combination of Adobe Illustrator and Adobe

Photoshop to give a simple, scientific look with added softness to the rendering.